Clinical Trials Program

Improving oral health with high-quality evidence derived from well-executed Phase I, II, III, and IV clinical trials is a high priority for NIDCR. A clinical trial is defined by NIH as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include placebo or other control) to evaluate the effects of those interventions on health-related biomedical or behavioral outcomes. Specific funding opportunity announcements solicit clinical trial applications.

Staff Contacts

Funding Opportunity Announcements

Title Staff Contact Opportunity Number Activity Code Expiration Date
NIDCR Award for Sustaining Outstanding Achievement in Research (SOAR) (R35 Clinical Trial Not Allowed) RFA-DE-20-002 R35
4DN Organization and Function in Human Health and Disease (U01 Clinical Trial Not Allowed) RFA-RM-20-005 U01
New Investigator Projects on 4DN Organization and Function in Human Health and Disease (U01 Clinical Trial Not Allowed) RFA-RM-20-006 U01
Transformative Technology Development for the Human BioMolecular Atlas Program (UG3/UH3 Clinical Tria RFA-RM-20-001 UG3, UH3
Tissue Mapping Centers for the Human BioMolecular Atlas Program (U54 Clinical Trial Not Allowed) RFA-RM-20-002 U54
4DN Centers for Data Integration, Modeling and Visualization (UM1 Clinical Trial Not Allowed) RFA-RM-20-004 UM1
Real Time Chromatin Dynamics and Function (U01 Clinical Trial Not Allowed) RFA-RM-20-003 U01
Pilot Projects Enhancing Utility and Usage of Common Fund Data Sets (R03 Clinical Trial Not Allowed) RFA-RM-19-012 R03
HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) RFA-NS-20-028 UG3, UH3
HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional) RFA-AT-20-004 UG3, UH3
Administrative Supplements for Research on Dietary Supplements (Admin Supp) PA-18-817 P30, P40, P50
NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) PA-18-484 R01
NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) PA-18-648 R13
NIDCR Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3) - Clinical Trial Required PAR-18-547 UG3, UH3
Change of Grantee Organization (Type 7 Parent) PA-18-590 C06, D43, D71
Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) PA-18-591 C06, D43, D71
Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Admin Supp) PA 18-591 C06, D43, D71
Academic Research Enhancement Award for Undergraduate-Focused Institutions (R15 - Clinical Trial Not Allowed) PAR-18-714 R15
Administrative Supplements to Promote Diversity in Small Businesses-SBIR/STTR (Admin Supp Clinical Trial Not Allowed) PA-18-837 R41, R42, R43
Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed) PA-18-906 C06, D43, D71
Clinical Trials Development for Co-Occurring Conditions in Individuals with Down syndrome: Phased Awards for INCLUDE (R61/R33 Clinical Trial Required) RFA-OD-20-003 R33, R61
NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required) PA-19-092 R21
NIH Administrative Supplements to Recover Losses Due to Hurricanes Harvey, Irma, and Maria Under the Bipartisan Budget Act of 2018 Non-Construction (Admin Supp Clinical Trial Optional) PA-18-936 D43, D71, DP1
Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed) PAR-19-134 R15
NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required) PA-19-091 R01
Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed) PAR-19-276 R03
Dissemination and Implementation Research in Health (R01 Clinical Trial Optional) PAR-19-274 R01
NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed) PAR-19-370 R03
Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44 Clinical Trial Not Allowed) PA-20-047 R43, R44
Development of Highly Innovative Tools and Technology for Analysis of Single Cells (STTR) (R41/R42 Clinical Trial Not Allowed) PA-20-025 R41, R42
NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed) PAR-20-060 U01