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Craniofacial Anomalies and Regeneration Section

Janice S. Lee, D.D.S., M.D., M.S., Chief

Mission

The mission of the CARS is to understand craniofacial development and bone formation through human disorders that affect the normal development, growth and formation of the craniofacial skeleton.  We focus on determining the genetic etiology and molecular changes in conditions such as hemifacial microsomia and mandibular prognathism, disorders that are identified at birth or may progress with growth respectively.  We intend to understand the progression of these conditions and develop predictive tools to guide clinicians in therapy and timing of intervention.  Through scientific high performance computing, we will use the latest methods in bioinformatics, biomedical imaging, and research information systems to further our understanding of these craniofacial anomalies.  Many of the conditions require reconstructive surgery and bone grafting due to underdevelopment or missing bone.  To address these reconstructive dilemmas that require significant surgery, we focus on examining the regenerative ability of postnatal bone marrow stromal stem cells and other mesenchymal tissues.  By developing animal models of skeletal defects, we are examining molecular and cellular variations that may induce self-repair or autotherapy and may be models for stem cell therapy.​

Get information about the Dental Clinical Research Fellows Training Program​.

Personnel

Summer Internship Program (SIP) Students 

2017
  • Jeremy Figueroa-Ortiz – University of Connecticut School of Dental Medicine
 
2016
  • Anthony Contratto - University of Missouri-Kansas City School of Dentistry
  • Preston Harris, Jr. - Meharry Medical College of Dentistry
  • Eric Coy - Towson University
  • Doga Tasdemir - Wooton High School
Past Lab Members - Where are they now?

  • John Le​ - University of Michigan School of Dentistry
  • Figen Cizmeci Senel, DDS, PhD​ - Ankara University School of Dentistry
  • Peter W. Fung, DMD, MS - University of North Carolina Oral and Maxillofacial Surgery Residency Program
  • Sooji Choi - University of Pennsylvania School of Dental Medicine
  • Rashmi Mishra, MPH, BDS​ - Oral Medicine Resident, University of Washington, Seattle, Washingto
  • Murat Sincan, MD - Director of Computational Medical Informatics, Sanford Health , Sioux Falls, South Dakota
  • Payal Verma, DMD, MPH - Oral and Maxillofacial Surgery Resident - University of Cincinnati, Ohio

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This page last updated: December 18, 2017