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Janice S. Lee, DDS, MD, MS

Janice S. Lee, DDS, MD, MSClinical Director
Chief, Craniofacial Anomalies and Regeneration Section

NATIONAL INSTITUTES OF HEALTH
BUILDING 10, ROOM 5-2531 MSC 1470
BETHESDA, MD 20892-1470

Phone: (301) 827-1647
Fax: (301) 480-0498
E-mail: leejs2@mail.nih.gov

Biographical Sketch

Janice S. Lee, DDS, MD, MS, has been the clinical director of NIDCR’s Division of Intramural Research since April 2015. Lee, a board-certified oral and maxillofacial surgeon, joined NIDCR as the deputy clinical director in August 2013. As chief of the Craniofacial Anomalies and Regenerative Section, Lee's clinical and translational research program is exploring the natural history and genetic etiology of craniofacial anomalies and growth abnormalities. Her research interests include bone regeneration and stem cell biology, craniofacial congenital anomalies, fibrous dysplasia, and McCune-Albright syndrome. In 2014, Dr. Lee initiated the Craniofacial Anomalies Team and began to conduct regular case reviews of patients who have craniofacial disorders, as well as provide consultations and treatments to patients at the NIH Clinical Center.

Before joining NIDCR in August 2013, Dr. Lee was professor of clinical oral and maxillofacial surgery and departmental vice chair in the Department of Oral & Maxillofacial Surgery at the University of California, San Francisco. Lee's clinical practice focused on craniofacial skeletal reconstruction for people born with cleft lip and palate and other craniofacial anomalies, especially hemifacial microsomia.

Dr. Lee earned a D.D.S. and an M.S. from the University of California, Los Angeles School of Dentistry and an M.D. from Harvard Medical School. She completed a residency in oral and maxillofacial surgery at Massachusetts General Hospital/Harvard University and a two-year research fellowship in NIDCR’s Craniofacial and Skeletal Diseases Branch. Dr. Lee has published nearly 50 peer-reviewed journal articles, dozens of abstracts and poster presentations, and several book chapters.

Research Interests/Scientific Focus

For a description of research interests and areas of scientific focus, please see the Craniofacial Anomalies and Regeneration Section.

Selected Publications

  1. Lee JS, FitzGibbon E, Butman JA, Dufresne CR, Kushner H, Wientroub S, Robey PG, Collins MT. Normal vision despite narrowing of the optic canal in fibrous dysplasia. N Engl J Med. 2002 Nov 21; 347(21):1670-6.
  2. Akintoye SO, Lee JS, Feimster T, Booher S, Brahim J, Kingman A, Riminucci M, Robey PG, Collins MT. Dental characteristics of fibrous dysplasia and McCune-Albright syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Sep; 96(3):275-82.
  3. Lee JS, Tartaglia M, Gelb BD, Fridrich K, Sachs S, Stratakis CA, Muenke M, Robey PG, Collins MT, Slavotinek A.Phenotypic and genotypic characterization of Noonan-like/multiple giant cell lesion syndrome. J Med Genetics 42(2):11e, 2005.
  4. Lee JS, Shi S. SHED Repair Critical-size Calvarial Defects in Immunocompromised Mice. Oral Disease 14:428-434, 2008.
  5. Swasty D, Lee JS, Huang JC, Maki K, Gansky SA, Hatcher D, Miller AJ. Anthropometric analysis of the human mandibular cortical bone as assessed by cone-beam computed tomography. J Oral Maxillofac Surg. 2009 Mar; 67(3):491-500.
  6. Fan Z, Yamaza T, Lee JS, Yu J, Wang S, Fan G, Shi S, Wang CY. BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. Nat Cell Biol. 2009 Aug; 11(8):1002-9.
  7. Brown D, Lee JS, Huang J, Maki K, Gansky SA, Hatcher D, Miller AJ. Cross-sectional Human Mandibular Morphology as Assessed In Vivo by Cone Beam Computed Tomography in Patients with Different Vertical Facial Dimensions. AJODO 2011 Apr; 139: e377-89.
  8. Mankani MH, Afghani S, Franco J, Launey M, Marshall S, Marshall GW, Nissenson R, Lee JS, Tomsia AP, Saiz E. Lamellar spacing in cuboid hydroxyapatite scaffolds regulates bone formation by human bone marrow stromal cells. Tissue Eng Part A 2011. 17(11-12): 1615-23.
  9. Sears CR, Miller AJ, Chang MK, Huang JC, Lee JS. Comparison of pharyngeal airway changes on plain radiography and cone-beam computed tomography after orthognathic surgery. J Oral Maxillofac Surg. 2011 Nov; 69(11):e385-94.
  10. Baek C, Paeng JY, Lee JS, Hong J. Morphologic evaluation and classification of facial asymmetry using 3-dimensional computed tomography. J Oral Maxillofac Surg. 2012 May; 70(5):1161-9.
  11. Lee JS, FitzGibbon E, Chen YR, Kim J, Lustig L, Akintoye S, Collins MT, Kaban LB. Clinical Guidelines for the management of craniofacial fibrous dysplasia. Orphanet J Rare Dis May 24; 7 Suppl 1;S2, epub 2012 May 24
  12. Saiz E, Zimmermann EA, LeJS, Wegst UGH, Tomsia AP. Perspectives on the role of nanotechnology in bone tissue engineering. Dental Materials, epub Aug 14, 2012
  13. Huang J, Ten E, Liu G, Finzen M, Yu W, LeJS, Saiz E, Tomsia A. Biocomposites of pHEMA with HA/β -TCP (60/40) for bone tissue engineering: Swelling, hydrolytic degradation, and in vitro behavior. Polymer 54(3):1197-1207. Epub Dec 21, 2012; Feb 5, 2013.
  14. Young N, Bekemezian S, Miller A, Lee JS, Marcucio R. Predictive modeling analysis of craniofacial skeletal and soft tissue. AJODO (accepted)
  15. Srour MK, Fogel JL, Yamaguchi KT, Montgomery AP, Izuhara AK, Misakian AL, Lam S, Lakeland KL, Lee JS, Mariani FV. Natural large-scale regeneration of rib cartilage in a mouse model. JBMR 2015 Feb;30(2):297-308. doi: 10.1002/jbmr.2326.

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This page last updated: February 07, 2017