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E-173-1998: ASSAY FOR THE DETECTION OF A VARIETY OF TUMORS IN BIOLOGICAL SPECIMENS

E-173-1998 is a broad platform technology directed towards cancer diagnostics. Patent protection was obtained in the United States and is available for licensing through the NIH Office of Technology Transfer (OTT). The technology is based on the small integrin-binding ligand, n-linked glycoprotein family--termed SIBLINGS--associated with an integral membrane structural protein called integrin. These proteins were originally discovered in basic research studies of differentiation and development.  Later, they were found to play an important role in cancer, which shares many properties of cells found in early developmental processes. More information about the role of SIBLINGS in cancer is available in the publications listed below.

Markets 

  • Clinical Diagnostics
  • Prostate Cancer
  • Multiple Myeloma
  • Breast Cancer
  • Lung Cancer
  • Thyroid Cancer

Announcements


October 7, 2009
Serum Marker for Prostate Cancer Improves PSA Test

  
May 1, 2000
Assay for the Detection of a Variety of Tumors in Biological Specimens 

Publications

Small integrin-binding proteins as serum markers for prostate cancer detection. 
Jain A, McKnight DA, Fisher LW, Humphreys EB, Mangold LA, Partin AW, Fedarko NS Clinical Cancer Research (2009) 15(16):5199-207
http://www.ncbi.nlm.nih.gov/pubmed/19671866 

Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer.
Bellahcène A, Castronovo V, Ogbureke KU, Fisher LW, Fedarko NS.
Nat Rev Cancer. 2008 Mar;8(3):212-26.
http://www.ncbi.nlm.nih.gov/pubmed/18292776

Low dentin matrix protein 1 expression correlates with skeletal metastases development in breast cancer patients and enhances cell migratory capacity in vitro.
Bucciarelli E, Sidoni A, Bellezza G, Cavaliere A, Brachelente G, Costa G, Chaplet M, Castronovo V, Bellahcène A.
Breast Cancer Res Treat. 2007 Sep;105(1):95-104.
http://www.ncbi.nlm.nih.gov/pubmed/17136477

Small integrin binding ligand N-linked glycoprotein gene family expression in different cancers.
Fisher LW, Jain A, Tayback M, Fedarko NS.
Clin Cancer Res. 2004 Dec 15;10(24):8501-11. 
http://www.ncbi.nlm.nih.gov/pubmed/15623631

Three small integrin binding ligand N-linked glycoproteins (SIBLINGs) bind and activate specific matrix metalloproteinases.
Fedarko NS, Jain A, Karadag A, Fisher LW.
FASEB J. 2004 Apr;18(6):734-6. 
http://www.ncbi.nlm.nih.gov/pubmed/14766790

Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density.
Jain A, Fedarko NS, Collins MT, Gelman R, Ankrom MA, Tayback M, Fisher LW.
J Clin Endocrinol Metab. 2004 Aug;89(8):4158-61.
http://www.ncbi.nlm.nih.gov/pubmed/15292364

Evaluation of osteopontin as biomarker for pancreatic adenocarcinoma.
Koopmann J, Fedarko NS, Jain A, Maitra A, Iacobuzio-Donahue C, Rahman A, Hruban RH, Yeo CJ, Goggins M.
Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):487-91.
http://www.ncbi.nlm.nih.gov/pubmed/15006928

Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer.
Fedarko NS, Jain A, Karadag A, Van Eman MR, Fisher LW.
Clin Cancer Res. 2001 Dec;7(12):4060-6.
http://www.ncbi.nlm.nih.gov/pubmed/11751502

Factor H binding to bone sialoprotein and osteopontin enables tumor cell evasion of complement-mediated attack.
Fedarko NS, Fohr B, Robey PG, Young MF, Fisher LW.
J Biol Chem. 2000 Jun 2;275(22):16666-72.
http://www.ncbi.nlm.nih.gov/pubmed/10747989

Up-regulation of SIBLING proteins and correlation with cognate MMP expression in oral cancer.
Ogbureke KU, Nikitakis NG, Warburton G, Ord RA, Sauk JJ, Waller JL, Fisher LW.
Oral Oncol. 2007 Oct;43(9):920-32.
http://www.ncbi.nlm.nih.gov/pubmed/17306612

Expression of dentin sialophosphoprotein in human prostate cancer and its correlation with tumor aggressiveness.
Chaplet M, Waltregny D, Detry C, Fisher LW, Castronovo V, Bellahcène A.Int J Cancer. 2006 Feb 15;118(4):850-6.
http://www.ncbi.nlm.nih.gov/pubmed/16108038

 

Patents

US Patent 6,995,018 Issued Feb 7, 2006 
COMPLEX FORMED BY N-LINKED GLYCOPROTEINS (SIBLINGS) AND FACTOR H
Patent Database (text version)
Patent Database (original document)


Technology Transfer Managers

The Licensing and Patent Managers (LPM) in the NIH Office of Technology Transfer (OTT) take the lead on license negotiations for all NIH institutes. The NIDCR Technology Development Coordinator (TDC) facilitates interactions between NIDCR investigators and commercial partners, including negotiating CRADAs and other collaborative agreements. Our goal is to benefit public health through the transfer and development of NIDCR's basic research findings.

NIH: Jennifer S Wong - Licensing
Licensing and Patent Manager (LPM)
NIH Office of Technology Transfer (OTT)
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-4633
Fax: 301-402-0220 
Email: wongje@mail.nih.gov
NIDCR: David W. Bradley - Collaborative Opportunities
Technology Development Coordinator (TDC)
Intramural Technology Transfer Office
National Institute of Dental and Craniofacial Research (NIDCR)
BLDG 10 RM 1N103
10 CENTER DR MSC 1197
BETHESDA, MD  20892-1197
Phone: 301-402-0540
Fax: 301-496-1005
Email: bradleyda@nidcr.nih.gov

 

Inventors

NIDCR receives $60 million per year in funding for the intramural research program and has a scientific staff of 160. 

The scientists who conceived the ideas behind the E-173-1998 invention are:

Larry W Fisher
Matrix Biochemistry Section
Craniofacial and Skeletal Diseases Branch
Division of Intramural Research
National Institute of Dental and Craniofacial Research (NIDCR)
BUILDING 30 ROOM 223
30 CONVENT DR MSC 4320
BETHESDA MD 20892-4320
Phone: 301-496-5769
Fax: 301-402-0824
Email:  lfisher@dir.nidcr.nih.gov

Neal S Fedarko (formerly at NIDCR)
Core Lab Director
Johns Hopkins Bayview
Clinical Research Unit
JHBMC 5A64 JHAAC
Phone: 410-550-2632
Fax: 410-550-1007
Email:  ndarko@jhmi.edu

Marian F Young
Molecular Biology of Bones and Teeth Section
Craniofacial and Skeletal Diseases Branch
Division of Intramural Research
National Institute of Dental and Craniofacial Research (NIDCR)
BUILDING 30 ROOM 222
30 CONVENT DR MSC 4320
BETHESDA MD 20892-4320
Phone: 301-496-8860 
Email: myoung@dir.nidcr.nih.gov

 

 

  

DHHS Ref No. E-173-1998

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This page last updated: May 28, 2014