Dr. Mays leads a clinical and translational research unit that investigates oral mucosal immunity, by using chronic graft-versus-host disease (cGVHD) as a model for study. cGVHD is an autoimmune-like condition that manifests after allogeneic hematopoietic stem cell transplantation. Symptoms include salivary gland dysfunction, oral lesions, and limited mouth-opening from perioral fibrosis. The underlying immunologic events that target the oral cavity and the mechanisms that drive the pathogenic process, particularly in salivary glands, are not well-understood. Consequently, targeted therapeutics are limited. Dr. Mays’ research program aims to elucidate the underlying immune process of cGVHD in the oral cavity (with a focus on the salivary glands), and then translate that knowledge into improved monitoring and therapeutics for people with cGVHD.
Dr. Jacqueline W. Mays received a B.S. in biology and chemistry from Valparaiso University, Ind., and a Ph.D. in oral biology and a D.D.S. from the College of Dentistry, The Ohio State University. Dr. Mays was awarded a Master of Health Sciences in Clinical Research from the College of Medicine at Duke University. Dr. Mays performed post-doctoral work at the National Institute of Allergy and Infectious Diseases (NIAID) on influenza viral protein expression and the anti-viral mucosal immune response, and subsequently completed a Clinical Research Fellowship at NIDCR focused on chronic Graft-versus-Host Disease (cGVHD) in the oral cavity. Dr. May was appointed chief of the Oral Immunobiology Unit at NIDCR in 2015. Dr. Mays’ laboratory is focused on translational investigation of cGVHD pathobiology and the development of new therapies for the oral cavity.
- Hakim FT, Memon S, Jin P, Imanguli MM, Wang H, Rehman N, Yan XY, Rose J, Mays JW, Dhamala S, Kapoor V, Telford W, Dickinson J, Davis S, Halverson D, Naik HB, Baird K, Fowler D, Stroncek D, Cowen EW, Pavletic SZ, Gress RE. Upregulation of IFN-Inducible and Damage-Response Pathways in Chronic Graft-versus-Host Disease. J Immunol. 2016 Nov 1;197(9):3490-3503.
- Bassim CW, Fassil H, Mays JW, Edwards DA, Baird K, Steinberg SM, Cowen EW, Naik H, Datiles M, Gress RE, Pavletic SZ. Oral Disease Profiles in Chronic Graft versus Host Disease. J Dent Res. 2015 Apr;94(4):547-54.
- Bassim CW, Fassil H, Mays JW, Edwards D, Baird K, Steinberg SM, Williams KM, Cowen EW, Mitchell SA, Cole K, Taylor T, Avila D, Zhang D, Pulanic D, Grkovic L, Fowler D, Gress RE, Pavletic SZ. Validation of the National Institutes of Health chronic GVHD Oral Mucosal Score using component-specific measures. Bone Marrow Transplant. 2014 Jan;49(1):116-21.
- Bassim CW, Ambatipudi KS, Mays JW,Edwards DA, Swatkoski S, Fassil H, K, Baird K, Gucek M, Melvin JE, Pavletic SZ. Quantitative Salivary Proteomic Differences in Oral Chronic Graft-versus-Host Disease. J Clin Immun. 2012 Dec;32(6):1390-9.
- Mays J, Fassil H, Edwards D, Pavletic S, Bassim C. Oral chronic graft-versus-host disease: current pathogenesis, therapy, and research. Oral Dis. 2013 May;19(4):327-46.
- Mays JW, Sarmadi M, Moutsopoulos NM. Oral manifestations of systemic autoimmune and inflammatory diseases: diagnosis and clinical management. J Evid Based Dent Pract. 2012 Sep;12(3 Suppl):265-82.
- Mays JW, Powell ND, Hunzeker JT, Hanke ML, Bailey MT, Sheridan JF. Stress and the anti-influenza immune response: repeated social defeat augments clonal expansion of CD8+T cells during primary influenza A viral infection. J Neuroimmunol. 2012 Feb 29;243(1-2):34-42.
- Hickman HD, Li L, Reynoso GV, Rubin EJ, Skon CN, Mays JW, Gibbs J, Schwartz O, Bennink JR, Yewdell JW. Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells. J Exp Med. 2011 Nov 21;208(12):2511-24.
- Mays J, Butts CL. Intercommunication between the neuroendocrine and immune systems: focus on myasthenia gravis. Neuroimmunomodulation. 2011;18(5):320-7.
- Mays JW, Bailey MT, Hunzeker JT, Powell ND, Papenfuss TL, Karlsson EA, Padgett DA, Sheridan JF. Influenza virus-specific immunological memory is enhanced by repeated social defeat. J Immun. 2010 Feb15; 184 (4): 2014-25.