The Gene Transfer Core provides research and technical services to NIDCR laboratories for the generation and preservation of genetically altered animal models. These services mainly include:
- providing consultations for developing strategies to generate transgenic and gene knockout mouse models;
- conducting gene targeting experiments using various mouse embryonic stem (ES) cells;
- performing injections of transgenic constructs and ES cell clones, as well as embryo transfers to generate founder and chimeric mice; and
- carrying out cryopreservation of mouse embryos and sperm to preserve valuable mouse lines.