Niki Moutsopoulos, DDS, PhD

Niki Moutsopoulos, D.D.S., Ph.D.

Tenure Track Clinical Investigator
Oral Immunity & Infection Unit

NIH/NIDCR
Building 30, Room 327
30 Convent Dr MSC 4320
Bethesda, MD 20892-4320
United States

(301) 435-7182
Research Interests

Dr. Moutosopoulos’ research is focused on oral-barrier immunity. Studies implement a bedside-to-bench approach and aim to understand the molecular and cellular basis of oral immunity in health, and in the common inflammatory disease of periodontitis. Periodontitis is a common inflammatory disease in humans, leading to destruction of tooth-supporting structures and tooth loss. Periodontal inflammation/dysbiosis is also associated with infections in other parts of the body, as well as systemic inflammatory conditions, which underscores the possibility of common mechanisms of susceptibility or disease triggering. Therefore, understanding mechanisms involved in the susceptibility and pathogenesis of periodontitis is not only critical for understanding the disease itself, but may provide insights into shared mechanisms among inflammatory diseases. Understanding the mechanisms that microbial triggers and host elements use to regulate oral immunity in health and disease is the focus of our research program.  

Biographical Sketch

Dr. Moutsopoulos received a DDS degree from the Aristotle University of Thessaloniki/Greece in 1998, completed her specialization in periodontology at the University of Maryland, and obtained a PhD in immunology while working in the laboratory of Dr. Sharon Wahl at NIDCR.  Dr. Moutsopoulos has worked as a clinical fellow at the NIH under the mentorship of Dr. Steven Holland (LCID/NIAID). Since 2010, Dr. Moutsopoulos has been an independent investigator building a clinical and translational program focused on basic oral immunology and susceptibility to the common human inflammatory disease periodontitis through the study of patients with monogenic immune defects.​

Selected Publications
Last Reviewed on
February 2018