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Odontogenic Diseases Program

Overview

The Odontogenic Diseases Program supports basic and translational science research on craniofacial skeletal biology, including tooth biology, and promotes multidisciplinary approaches to advance the understanding of normal and abnormal processes underlying oral, dental, and craniofacial diseases and disorders from the molecular to the organismal level. This program also supports the development of tools and methods to further advance knowledge and capabilities for study of and in tissues that are mineralized as well as the following areas:

DOC Precision Medicine Program

Overview

The Dental, Oral, and Craniofacial (DOC) Precision Medicine Program supports research designed to identify the genetics and genomics underlying health, diseases, and conditions of the DOC complex. The program supports research that applies human and clinical genetics, multi-omics, systems biology, and data science approaches to achieve a holistic understanding of disease mechanisms and the interplay of genetic and other factors underlying DOC biology and health. Relevant research topics include, but are not limited to:

DOC Developmental Biology & Congenital Anomalies Program

Overview

The Dental, Oral, and Craniofacial (DOC) Developmental Biology & Congenital Anomalies Program supports basic and pre-translational research on processes that underpin the development of craniofacial (CF) structures. Projects falling within the purview of this program may range from neural crest specification early in embryogenesis to patterning, differentiation, and morphogenesis of the craniofacial complex and subsequent development of teeth and craniofacial sutures.

DOC Computational Biology & Data Science Program

Overview

The Dental, Oral, and Craniofacial (DOC) Computational Biology and Data Science Program promotes data-driven research in DOC biology, disorders, and health disparities to inform and develop prevention strategies, diagnostics, and therapies of DOC disorders for all individuals.

DOC Behavioral Interventions & Assessments Program

Overview

The Dental, Oral, Craniofacial (DOC) Behavioral Interventions and Assessments Program focuses on behavioral treatments, health promotion and maintaining good health, and intervention and outcome research. Typically, such research is conducted in medical, dental, community, healthcare, social, and related settings. Research incorporating comorbid or related medical conditions as well as person or systemic indices are especially welcome. Relevant research topics include, but are not limited to:

Behavioral & Biomedical Processes for DOC & Systemic Health Outcomes Program

Overview

This Behavioral and Biomedical Processes for Dental, Oral, Craniofacial (DOC) and Systemic Health Outcomes Program supports projects that utilize knowledge across disciplines including the behavioral, biomedical, social, and public health sciences to advance DOC, and systemic health for all. Projects should be designed to enhance our understanding of how and why humans initiate, adopt, maintain, and sustain behaviors that impede or promote optimal health and well-being within NIDCR’s research mission.

Implementation Science for HIV/AIDS Oral Health Program

Overview

The Implementation Science for HIV/AIDS Oral Health Program supports studies that advance innovative strategies for the adoption and integration of evidence-based HIV and oral health practices and interventions to end the HIV epidemic and achieve oral health for all. Relevant research topics include, but are not limited to:

DOC Health Disparities Program

Overview

The Dental, Oral, Craniofacial (DOC) Health Disparities Program supports scientifically rigorous, community-engaged research that helps generate scalable, evidence-based strategies to address DOC health disparities in communities to achieve health for all. Despite remarkable improvements in the oral health of Americans, chronic DOC diseases and conditions remain among the most common health problems across the lifespan. The conditions can be particularly prevalent and severe for individuals and communities that face economic or other barriers to health care.

Oral & Systemic Health Integration Program

Overview

The Oral and Systemic Health Integration Program aims to promote clinical research to advance knowledge in diagnosis, prevention, and management of Dental, Oral, and Craniofacial (DOC) diseases in the context of systemic health. The program supports research that evaluates the interaction between oral health and general health throughout the lifespan considering advances in science and health care integration to investigate promising directions for improving oral and comprehensive health. Relevant research topics include, but are not limited to:

Biomedical Clinical Trials of DOC Conditions Program

Overview

The Biomedical Clinical Trials of Dental, Oral, and Craniofacial (DOC) Conditions Program supports well-designed and well-executed clinical trials (Phase I, II, III, and IV) that test interventions and have the potential to improve DOC health. These trials should provide scientific evidence that can be used for establishing or changing the standard of care, or for consideration of a change in health care policy.