English

Overview

The Oral Microbiome and Polymicrobial Disease Program supports basic and translational research on the role of bacteria, fungi and viruses in health and disease in the oral cavity. Topics include examining the role of the oral microbiome in health and disease; microbial virulence and pathogenesis, including oral opportunistic pathogens; and prevention, diagnosis and treatment of microbial infections. NIDCR encourages research on understanding the complexities of the oral microbiome and the importance in oral and overall health.

Overview

The Oral Mucosa and Cancer Biology Program supports basic and translational research to improve detection and treatment of cancers of the oral cavity, pharynx, and salivary glands. The program aims to advance knowledge in mechanisms that influence tumor initiation, promotion, and progression, and development of innovative biomarkers and diagnostic technologies to improve medical decision and treatment evaluation. Examples of supported research include:

Overview

The Orofacial Pain Conditions and Neuroscience Program supports basic and translational research on orofacial pain and neuropathies; temporomandibular joint and muscle disorders; development of biomarkers for diagnostics and prognostics; and development of therapeutics. Basic and translational studies on nervous system mechanisms and/or regulation in craniofacial conditions and disorders are also of interest.

Overview

The DOC Biomaterials, Devices & Clinical Technologies Program catalyzes end-to-end discovery, design, technology development, and translation of innovative materials, devices, and integrated systems intended to restore, preserve, manage, and optimize dental, oral, and craniofacial (DOC) health.

Overview

The Dental, Oral, and Craniofacial (DOC) Regenerative Medicine Program supports basic and translational research employing interdisciplinary approaches for the reconstruction, repair, and regeneration of DOC tissues that have become impaired by disease or injury.

Overview

The Immunomodulatory Oral Science Program encourages pre-clinical and translational research on immune aspects of Dental, Oral, and Craniofacial (DOC) diseases, including oral lesions and periodontal disease. Innovative approaches to address oral diseases sequelae in the context of systemic conditions such as cardiovascular disease, diabetes, pulmonary and autoimmune problems are also of interest. The program encourages translational research in the following areas:

Overview

The Odontogenic Diseases Program supports basic and translational science research on craniofacial skeletal biology, including tooth biology, and promotes multidisciplinary approaches to advance the understanding of normal and abnormal processes underlying oral, dental, and craniofacial diseases and disorders from the molecular to the organismal level. This program also supports the development of tools and methods to further advance knowledge and capabilities for study of and in tissues that are mineralized as well as the following areas:

Overview

The Dental, Oral, and Craniofacial (DOC) Precision Medicine Program supports research designed to identify the genetics and genomics underlying health, diseases, and conditions of the DOC complex. The program supports research that applies human and clinical genetics, multi-omics, systems biology, and data science approaches to achieve a holistic understanding of disease mechanisms and the interplay of genetic and other factors underlying DOC biology and health. Relevant research topics include, but are not limited to: