Dr. Mezey is interested in the biology of bone marrow stromal cells (MSCs). These cells are able to suppress the immune system and have been tested in autoimmune diseases. The same cells also support hematopoiesis (making of blood cells) in the bone marrow. Her studies suggest that injected MSCs might be able to alleviate sepsis in patients. Studies also reveal that—through a different mechanism—these cells might reduce the symptoms of asthma. Her group studies ways in which to improve the efficiency of these cells in fighting auto-immune diseases. In addition, they are studying how MSCs might regulate red cell production in the bone marrow of patients with anemia. Dr. Mezey’s group collaborates with clinicians to find out the best ways to use the unique properties of these cells in patients, and to prime MSCs for targeted use.
Dr. Éva Mezey earned her M.D. from the Semmelweis University Medical School in Budapest, Hungary, where she taught neuroanatomy, and began doing research under the guidance of Drs. Janos Szentagothai and Miklos Palkovits. She then worked with Prof. David DeWied in Utrecht. Dr. Mezey received a Ph.D. in neuroendocrinology from the Hungarian Academy of Sciences. Dr. Mezey came to NIH as a postdoctoral fellow in the Laboratory of Cell Biology at NIMH and later at NINDS. At NIDCR, Dr. Mezey established the Adult Stem Cell Section to study the biology of bone marrow derived stem cells (MSCs). Dr. Mezey has received a Doctor of Science (D.Sc.) degree and has been elected to the Hungarian Academy of Sciences. She is a member of the International Stem Cell Society and the Society for Neuroscience.
- Nemeth K, Mezey É. Origin of stem cells in the BM niche: new clues from mastocytosis. Blood. 2016 Feb 11;127(6):670-02.
- Mezey É. On the origin of blood cells - hematopoiesis revisited. Oral Dis. 2016 May;22(4):247-248.
- Nemeth K, Wilson TM, Ren JJ, Sabatino M, Stroncek DM, Krepuska M, Bai Y, Robey PG, Metcalfe DD, Mezey É. Impaired function of bone marrow stromal cells in systemic mastocytosis. Stem Cell Res. 2015 Jul;15(1):42-53.
- Mezey É, Nemeth K. Mesenchymal stem cells and infectious diseases: Smarter than drugs. Immunol Lett. 2015 Dec;168(2):208-214.
- Nemeth K, Wilson T, Rada B, Parmelee A, Mayer B, Buzas E, Falus A, Key S, Masszi T, Karpati S, Mezey É. Characterization and function of histamine receptors in human bone marrow stromal cells. Stem Cells. 2012 Feb;30(2):222-231.
- Tran SD, Redman RS, Barrett AJ, Pavletic SZ, Key S, Liu Y, Carpenter A, Nguyen HM, Sumita Y, Baum BJ, Pillemer SR, Mezey É Microchimerism in salivary glands after blood- and marrow-derived stem cell transplantation. Biol Blood Marrow Transplant. 2011 Mar;17(3):429-433.
- Mezey É. The therapeutic potential of bone marrow-derived stromal cells. J Cell Biochem. 2011 Oct;112(10):2683-7.
- Brown JM, Nemeth K, Kushnir-Sukhov NM, Metcalfe DD, Mezey É. Bone marrow stromal cells inhibit mast cell function via a COX2-dependent mechanism. Clin Exp Allergy. 2011 Apr;41(4):526-34.
- Nemeth K, Keane-Myers A, Brown JM, Metcalfe DD, Gorham JD, Bundoc VG, Hodges MG, Jelinek I, Madala S, Karpati S, Mezey É. Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5652-7.
- Khalili S, Liu Y, Sumita Y, Maria OM, Blank D, Key S, Mezey É, Tran SD. Bone marrow cells are a source of undifferentiated cells to prevent Sjogren's syndrome and to preserve salivary glands function in the non-obese diabetic mice. Int J Biochem Cell Biol. 2010 Nov;42(11):1893-9.