Connective Tissue Section
Director, NIH’s National Center for Complementary and Integrative Health
Lab: Building 30, Room 532
NCCIH Office: Building 31, Room 2B11
Bethesda, MD 20892
Dr. Langevin is interested in exploring how to keep connective tissue flexible and free from pain, slow aging, and increase the health of the whole body. One limitation of conventional medicine is its fragmentation of the body into separate systems and body parts. Connective tissue is a body-wide network that connects all its systems and parts, making it important for the integrated functioning of the whole body. Dr. Langevin’s previous work has focused on the role of connective tissue in chronic pain and the mechanisms of acupuncture, manual, and movement-based therapies. Her goal at NIDCR is to understand how mechanical forces may help connective tissue stay strong and flexible, allow for successful healing after injury, reduce inflammation, and prevent cancer.
Dr. Helene Langevin holds an MD degree from McGill University, Montreal. She completed a postdoctoral research fellowship in neurochemistry at the MRC Neurochemical Pharmacology Unit in Cambridge, England, and a residency in internal medicine and fellowship in endocrinology and metabolism at The Johns Hopkins Hospital, Baltimore.
In November 2018, Dr. Langevin was sworn in as director of the National Center for Complementary and Integrative Health (NCCIH). Prior to her arrival, she was director of the Osher Center for Integrative Medicine, jointly based at Brigham and Women's Hospital and Harvard Medical School, Boston, and professor in residence of medicine at Harvard Medical School. She also was a visiting professor of neurological sciences at the University of Vermont Larner College of Medicine, Burlington.
- Berrueta L, Bergholz J, Munoz D, Muskaj I, Badger JG, Shukla A, Kim HJ, Zhao J, Langevin HM. Stretching reduces tumor growth in mouse breast cancer model. Scientific Reports. 2018;8(1):7864.
- Berrueta L, Muskaj I, Olenich S, Butler, T, Badger JG, Colas R, Spite M, Serhan CN, Langevin HM. Stretching impacts inflammation resolution in connective tissue. Journal of Cellular Physiology. 2016;231(7):1621-7.
- Corey SM, Vizzard MA, Bouffard NA, Badger GJ, Langevin HM. Stretching of the back improves gait, mechanical sensitivity and connective tissue inflammation in a rodent model. PLOS ONE. 2012;7(1):e29831.
- Langevin HM, Fox JR, Koptiuch C, Badger GJ, Greenan-Naumann AC, Bouffard NA, Konofagou EE, Lee WN, Triano JJ, Henry SM. Reduced thoracolumbar fascia shear strain in human chronic low back pain. BMC Musculoskeletal Disorders. 2011;12:203.
- Langevin HM, Stevens-Tuttle D, Fox JR, Badger GJ, Bouffard NA, Krag MH, Wu J, Henry SM. Ultrasound evidence of altered lumbar connective tissue structure in human subjects with chronic low back pain. BMC Musculoskeletal Disorders. 2009;10:151.
- Langevin HM, Bouffard NA, Badger GJ, Churchill DL, Howe AK. Subcutaneous tissue fibroblast cytoskeletal remodeling induced by acupuncture: Evidence for a mechanotransduction-based mechanism. Journal of Cellular Physiology. 2006;207(3):767-74.
- Langevin HM, Bouffard NA, Badger GJ, Iatridis JC and Howe AK. Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo. American Journal of Physiology-Cell Physiology. 2005;288(3):C747-56.
- Langevin HM, Churchill DL, Fox JR, Badger GJ, Garra BS, Krag MH. Biomechanical response to acupuncture needling in humans. Journal of Applied Physiology. 2001;91(6):2471-8.
- Langevin HM, Churchill DL, Cipolla MJ. Mechanical signaling through connective tissue: A mechanism for the therapeutic effect of acupuncture. FASEB Journal. 2001;15(12):2275-82.