Dr. Pamela Robey focuses on four main areas in skeletal cell biology: 1) determination of the characteristics and the biological properties of post-natal bone marrow stromal cells (BMSCs), a subset of which are multipotent skeletal stem cells (SSCs), able to recreate cartilage, bone, cells that support blood formation and fat cells in the marrow; 2) elucidation of the role of enzymatic matrix remodeling in the maintenance of SSC function; 3) characterization of the role that BMSCs/SSCs play in skeletal diseases; and, 4) development of techniques for cartilage and bone regeneration in human patients with skeletal defects. In addition to using BMSCs for tissue engineering, Dr. Robey and her group also explore the potential of pluripotent stem cells to differentiate into cartilage and bone as another source of cells for skeletal regeneration.
Dr. Robey received her BA from Susquehanna University in Selinsgrove, PA, and her MS and PhD from the Catholic University in Washington, DC. She did her post-doctoral work at the National Institute of Arthritis, Metabolism and Digestive Diseases (now the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)) on the role of defective phosphorylation of enzymes leading to lysosomal storage disease, and a staff fellowship in the National Eye Institute, where she studied retinal and ocular connective tissue diseases. Dr. Robey joined NIDCR in 1983 and established reproducible methods for culturing human bone-forming cells, in order to study the development of mineralized matrix formation. In 1992, Dr. Robey was appointed chief of Skeletal Biology Section. Dr. Robey has served as a Co-Coordinator of the NIH Bone Marrow Stromal Cell Transplantation Center (2008-2013), and is currently the acting Scientific Director of the NIH Stem Cell Characterization Facility.
- Sacchetti B, Funari A, Remoli C, Giannicola G, Kogler G, Liedtke S, Cossu G, Serafini M, Sampaolesi M, Tagliafico E, Tenedini E, Saggio I, Robey PG, Riminucci M, Bianco P. No Identical "Mesenchymal Stem Cells" at Different Times and Sites: Human Committed Progenitors of Distinct Origin and Differentiation Potential Are Incorporated as Adventitial Cells in Microvessels. Stem Cell Reports. 2016 Jun 14;6(6):897-913.
- Sworder BJ, Yoshizawa S, Mishra PJ, Cherman N, Kuznetsov SA, Merlino G, Balakumaran A, Robey PG. Molecular profile of clonal strains of human skeletal stem/progenitor cells with different potencies. Stem Cell Res. 2015 May;14(3):297-306.
- Bianco P, Robey PG. Skeletal stem cells. Development. 2015 Mar 15;142(6):1023-7.
- Balakumaran A, Mishra PJ, Pawelczyk E, Yoshizawa S, Sworder BJ, Cherman N, Kuznetsov SA, Bianco P, Giri N, Savage SA, Merlino G, Dumitriu B, Dunbar CE, Young NS, Alter BP, Robey PG. Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders. Blood. 2015 Jan 29;125(5):793-802.
- Robey PG, Kuznetsov SA, Ren J, Klein HG, Sabatino M, Stroncek DF. Generation of clinical grade human bone marrow stromal cells for use in bone regeneration. Bone. 2015 Jan;70:87-92.