Roberto Weigert, Ph.D.

Roberto Weigert, Ph.D.

Adjunct Senior Investigator, NIDCR

Senior Investigator, NCI

Intracellular Membrane Trafficking Section, NIDCR & Laboratory of Cellular and Molecular Biology, NCI

Building 37, Room 2050B
37 Convent Dr.
Bethesda, MD 20892-4256
United States

Research Interests

The two central questions that drive Dr. Weigert’s research are how membranes continuously change their shape and composition during trafficking events such as endocytosis and exocytosis at the plasma membrane, and how these processes are deregulated during tumor progression, invasion, and metastasis in head and neck squamous cell carcinomas. Specifically, Dr. Weigert and his team have directed their efforts toward understanding the spatiotemporal coordination of actin cytoskeleton, cell signaling, and cellular metabolism, which is essential in controlling membrane remodeling. To address these questions, Dr. Weigert and his colleagues have developed Intravital Subcellular Microscopy (ISMIC), which combines light microscopy techniques, such as two-photon and confocal microscopy, to enable the direct observation of the intracellular process in live animals. This has been complemented with the development of a series of pharmacological, molecular, and genetic tools that have made possible the investigation of cellular processes in vivo at a molecular level.

Biographical Sketch

Dr. Roberto Weigert obtained a B.Sc. in chemistry from the University of Catania, Italy, after which he joined the department of cell biology at the Mario Negri Institute. In 2000, Dr. Weigert received a Ph.D. from the Open University of London. In 2001, Dr. Weigert joined the National Heart, Lung, and Blood Institute (NHLBI) at NIH as a research fellow in the Laboratory of Cell Biology. In 2006, Dr. Weigert joined NIDCR as chief of the Intracellular Membrane Trafficking Unit. In 2015, Dr. Weigert joined the Laboratory of Cellular and Molecular Biology at the National Cancer Institute (NCI).

Selected Publications
Last Reviewed on
November 2023