Rapid Initial Support for COVID-19 Research

This page lists the initial COVID-19 research projects that NIDCR funded nationwide through its extramural programs. The projects seek to address critical needs, such as minimizing infection risk in dental environments, improving SARS-CoV-2 detection in saliva, and exploring mechanisms of viral entry into oral epithelial cells. The studies range from clinical to basic research, and many are conducted through the National Dental Practice-Based Research Network (National Dental PBRN).

Particle Topography and Aerosol Size Distribution in Dental Settings in COVID-19 Era

Drs. Omid Amili and George Choueiri
"This study could help us better understand the dynamics of particles potentially carrying SARS-CoV-2, and it could lead to evidence-based strategies to minimize the transmission of highly infectious respiratory diseases such as COVID-19." —Drs. Amili and Choueiri

Omid Amili & George Choueiri
University of Toledo

Aerosols generated during dental procedures may expose providers to SARS-CoV-2. To better understand aerosol dynamics in dental care environments, the scientists will develop a droplet- and aerosol-generating respiratory patient simulator equipped with a dental typodont. Dentists on the team will perform common procedures on the simulated patient in different dental office layouts, and aerosol particle concentration, accumulation, and dissipation over time will be characterized. The scientists will then use the system to measure the effectiveness of aerosol-reducing approaches during dental care. The findings could inform new strategies to mitigate aerosol spread in dental environments. Learn more on the National Dental PBRN website

Quantifying and Reducing Aerosol Generation in Dental Settings

Dr. Michael Joseph Durkin
“By studying aerosol generation in dental settings, we hope to help dentists categorize procedures into low, medium, and high-risk categories and to determine the most appropriate personal protective equipment measures and aerosol mitigation interventions for best protecting themselves and patients.” —Michael Joseph Durkin

Michael Joseph Durkin
Washington University

Dental procedures expose clinicians to oral secretions that can become aerosolized and may carry SARS-CoV-2, increasing the risk of transmission to dental healthcare professionals. The researchers will place sensors in clinics and on clinicians to measure aerosol particle size, quantity, and in-air duration during dentistry procedures in various clinical settings with different physical layouts. The “real world” data can help researchers identify aerosol-generating procedures and gauge the extent of aerosol particle spread throughout clinical practice spaces. The findings could inform strategies for reducing aerosol spread during clinical care. Learn more on the National Dental PBRN website

Pragmatic Return to Effective Dental Infection Control through Triage and Testing (PREDICT)

Dr. Cecile Feldman
“We aim to identify and support protocols that can make dental practices safer and increase dental professionals’ and patients’ confidence in procedures being followed.” —Cecile Feldman

Cecile Feldman
Rutgers University

Amid the COVID-19 pandemic, dental offices have employed risk mitigation protocols, but their usefulness is not fully known. To address the issue, the scientists will develop and test the feasibility of several risk-mitigation strategies, including the use of point-of-care testing for SARS-CoV-2 infection. The results are aimed at increasing the safety and confidence of dental providers and their patients during care delivery. Learn more on the National Dental PBRN website

National Dental PBRN COVID-19 Research (CORE) Registry

Dr. Jeffrey L. Fellows
“By engaging dental providers in data collection, evaluation, dissemination of results, and assessment of subsequent practice changes, our study aims to help practitioners successfully and confidently manage coronavirus transmission risks and costs.” —Jeffrey L. Fellows

Jeffrey L. Fellows
Kaiser Foundation Hospitals

Dental procedures generate aerosols that can increase the risk of SARS-CoV-2 transmission in the clinic. The researchers will create a National Dental PBRN registry, called the COVID-19 REsearch Registry (CORE), to capture standardized data from approximately 2,000 practitioners about the approaches they use to reduce transmission risks and associated costs, and their comfort with these methods. The researchers will use a learning health system to present survey results to participating practitioners, followed by a reassessment to evaluate changes in mitigation approaches and comfort levels. The CORE Registry will establish an infrastructure to support the design and conduct of future clinical and implementation studies. Learn more on the National Dental PBRN website

Resources and Support for National Dental PBRN COVID-19 Research

Drs. Gregg H. Gilbert and Mary Ann McBurnie
These resources will expedite development, implementation, and dissemination of studies designed to directly impact everyday clinical practice.” —Drs. Gilbert and McBurnie

Gregg H. Gilbert
National Dental PBRN Administrative and Resource Center
University of Alabama at Birmingham

Mary Ann McBurnie
National Dental PBRN Network Coordinating Center
Kaiser Foundation Research Institute

Two hubs make up the central infrastructure of the National Dental PBRN: the Network Coordinating Center, which oversees data coordination, collection, management, and storage; and the Administrative and Resource Center, which provides resources such as practitioner recruitment and engagement, research-conduct training, communications and dissemination, and management of the network’s single institutional review board. The two centers will jointly provide budgetary support and access to their respective resources for studies conducted through the National Dental PBRN that aim to better understand COVID-19’s impact in dental settings and how to best mitigate its risks to patients and providers. Learn more about the Administrative and Resource Center and the Network Coordinating Center on NIH RePORTER.

Assess an Innovative mDentistry eHygiene Strategy Amid the COVID-19 Pandemic

Drs. Kopycka-Kedzierawski and Xiao
“The mDentistry eHygiene study may inform modification of the dental service system by providing a safer environment and preserving personal protective equipment amid the COVID-19 pandemic and other infectious disease outbreaks.” —Drs. Kopycka-Kedzierawski and Xiao

Dorota Kopycka-Kedzierawski & Jin Xiao
University of Rochester

Amid the COVID-19 pandemic, dental healthcare professionals face the challenges of conserving resources and preventing cross-contamination. To see if virtual dental exams might help to address these concerns, scientists will collect data from 48 dental healthcare practitioners and 192 patients who will undergo an in-office visit with a hygienist and a virtual visit with a dentist. The researchers will assess the level of acceptance, barriers, and economic concerns of patients and practitioners, along with patients’ abilities to take intraoral photos using a digital mobile health tool. The findings could inform models for delivery of virtual oral exams that improve dental care access during public health emergencies and in general. Learn more on the National Dental PBRN website

Evaluating and Improving Personal Protective Equipment Use in Dental Settings

Dr. Jennie H. Kwon
“This study will expand our understanding of PPE use in the dental healthcare setting and provide evidence-based, pragmatic educational resources to dental healthcare providers to help them better protect themselves and patients from infectious threats such as SARS-CoV-2.” —Jennie H. Kwon

Jennie H. Kwon
Washington University

To protect themselves and patients during the pandemic, dental healthcare providers wear a range of personal protective equipment (PPE), including N95 masks, face shields, eye protection, and surgical gowns. Proper methods for taking PPE on and off—termed donning and doffing—help clinicians avoid contaminating themselves and the dental care environment. The researchers will assess dental clinicians’ current PPE use and then will observe and document protocol deviations and potential self-contamination (via fluorescent markers) as clinicians don and doff PPE. The findings will inform development of an educational video to train dental healthcare professionals to safely don and doff PPE. Learn more on the National Dental PBRN website

SARS-CoV-2 and the Oral Microbiome

Dr. Robert A. Burne
“Right now, the scientific community has virtually no understanding of how the oral microbiome may influence the host’s sensitivity to infection by bacterial, fungal, or viral pathogens. We hope to fill that void with our research, which could shed light on ways to manipulate the oral microbiota to diminish the transmission or severity of SARS-CoV-2 and other respiratory pathogens.” —Robert A. Burne

Robert A. Burne
University of Florida

Certain oral bacteria are thought to produce compounds that can curb infectivity of pathogens—a mechanism that may help combat SARS-CoV-2. Researchers will screen a large panel of Streptococcus—one of the most abundant types of bacteria in the oral cavity—to find strains that can impede SARS-CoV-2 binding to host cells. Identifying the bacterial genes and compounds responsible for this interference could lead to new interventions that diminish transmission and disease severity. Learn more on NIH RePORTER

Handheld Electrical Sensor for Rapid, Sensitive Detection and Quantification of SARS-CoV-2 from Saliva

Dr. Josephine F. Esquivel-Upshaw
“Having a sensor—a true point-of-care device—to test patients for the presence of SARS-CoV-2 can ease the trepidation many dental practitioners have about working in environments where aerosols are easily released. Such a device could help keep our community safe and minimize the spread of disease in dental settings.” —Josephine F. Esquivel-Upshaw

Josephine F. Esquivel-Upshaw
University of Florida

Diagnostic testing for SARS-CoV-2 typically involves uncomfortable nasopharyngeal swabs and the use of polymerase chain reaction (PCR) to detect viral RNA, a process that takes several hours and requires specialized lab equipment. To find a faster and less invasive testing method, the researchers developed a sensor that instead detects viral surface proteins (antigens). The sensor could detect SARS-CoV-2 at low concentrations in saliva in less than 30 seconds. Now, the scientists seek to optimize the sensitivity and specificity of the sensor and develop a miniaturized, handheld version that can be used in clinical and everyday settings. Learn more on NIH RePORTER

Coordinating Center to Help Eliminate/Reduce Oral Health Inequalities in Children

Stuart A. Gansky
“By seeking to clinically corroborate preliminary in vitro evidence that some mouth rinses inactivate SARS-CoV-2, study findings could have implications for oral healthcare safety (pre-procedure rinses) and for reducing oral and respiratory health symptoms.” —Stuart A. Gansky

Stuart A. Gansky
University of California, San Francisco

To help prevent COVID-19 transmission, experts have recommended that patients rinse with an antiseptic mouthwash before undergoing dental procedures. However, the effectiveness of this approach has not been scientifically evaluated. This NIDCR-supported coordinating center will provide administrative support for a University of California-funded pilot clinical trial to assess the effect of mouthwashes on viral load in COVID-19-infected adults. The findings could shed light on clinical care methods that better protect dental clinicians and patients from the virus. Learn more on NIH RePORTER

Mouthwash Use, Oral Nitric Oxide Metabolism and COVID-19

Kaumudi J. Joshipura & Evangelia Morou
“The biological properties of nitric oxide are directly relevant to SARS-CoV-2 infection, and our study will help elucidate that relationship by determining the role of nitric oxide production via commensal oral bacteria on clinical outcomes of COVID-19 infection.” —Drs. Joshipura and Morou

Kaumudi J. Joshipura & Evangelia Morou
University of Puerto Rico

Recent research indicates that certain types of antiseptic mouthwash can kill SARS-CoV-2 viruses, raising the possibility that mouthwash use could decrease oral viral load in infected people and potentially reduce the risk of transmission to others. However, by disrupting the oral microbial balance, regular use of mouthwash may also interfere with the production of nitric oxide, a key molecule that helps regulate inflammation and endothelial function and that has demonstrated antiviral properties against SARS-CoV-2. The researchers will evaluate the associations between mouthwash use, nitric oxide metabolism in the mouth, and COVID-19 outcomes in patients. The results could provide insight into the potential role of mouthwash in the diagnosis, prognosis, and outcomes of COVID-19 in patients. Learn more on NIH RePORTER

Community Intervention Modifications for Low-Income Urban Families after COVID-19

Dr. Molly A. Martin
“Our research will describe the experiences of low-income urban families with very young children during the COVID-19 pandemic, and the data we generate will guide future interventions to reduce health disparities.” —Molly A. Martin

Molly A. Martin
University of Illinois at Chicago

In a study funded by NIDCR prior to the COVID-19 pandemic, the researchers have been developing and testing interventions to reduce oral health disparities in low-income urban families. Now, the team seeks to understand how the pandemic has affected access to dental healthcare and social services among the 420 young children and their families currently enrolled in the study. The scientists will identify intervention needs in dental care access, oral health behaviors, nutrition, and mental health to help families establish healthy oral care habits that can outlive the pandemic. Learn more on NIH RePORTER

Identification of Genetic Risk and Protective Factors Associated with COVID-19

Cuong Q. Nguyen
“Determining whether a person’s HLA genotype affects their risk for COVID-19 severity could help us identify high-risk individuals and better protect our front-line professionals and patients.” —Cuong Q. Nguyen

Cuong Q. Nguyen
University of Florida

COVID-19 symptoms can range from mild to severe. Some scientists think genetic variation in human leukocyte antigens (HLAs)—a set of immune-stimulating proteins on the surfaces of host cells—could underlie differences in disease severity. To explore this possibility, researchers will genotype asymptomatic and symptomatic COVID-19 patients to understand how HLA genetic variations correlate with symptom severity. These variations could serve as genetic biomarkers for predicting COVID-19 severity, making it possible to identify and potentially protect susceptible individuals, including dental providers, healthcare professionals, and other front-line personnel working in high-risk environments. Learn more on NIH RePORTER

Impact of COVID-19-Related Dental Care Modifications in Cancer Patients

Mukund Seshadri
“Given cancer patients’ and dental providers’ increased susceptibility to COVID-19, development and evaluation of optimized clinical workflows is critical to safely deliver oral healthcare to cancer patients while ensuring that all dental clinic staff remain protected.” —Mukund Seshadri

Mukund Seshadri
Health Research Inc. & Roswell Park Cancer Institute

The pandemic has led to changes in the delivery of dental and oral healthcare. However, the impact of these changes, especially in high-risk populations such as cancer patients, is unknown. Using electronic health records and patient surveys, the researchers will assess how delays in care have affected high-risk cancer patients and survivors, including oral health complications related to cancer treatment. The group will also develop strategies to triage and manage the oral health of cancer patients through a combination of screening, SARS-CoV-2 testing, and teledentistry. Learn more on NIH RePORTER

Identification of Novel Host Proteins Involved in SARS-CoV-2 Trafficking

Bruce J. Shenker
“Our proof-of-principle study to determine the role of cellugyrin in the pathogenesis of SAR-CoV-2 infection in the oral-respiratory tract could shed light on early molecular mechanisms of infection and reveal promising targets for therapeutic interventions.” —Bruce J. Shenker

Bruce J. Shenker
University of Pennsylvania

One promising approach to combatting SARS-CoV-2 is to block the virus from entering host cells. To better understand how the virus gains entry, the scientists will examine a host cell protein called cellugyrin, which they propose plays a role in periodontitis. In earlier NIDCR-funded research, the scientists showed that cellugyrin is critical to the entry and movement of bacterial toxins within cells in the oral cavity, and they suspect that this “gateway” role may extend to viruses. The researchers will test whether cellugyrin is involved in SARS-CoV-2 entry into cells of the mouth and lungs, and if so, if it can be co-opted to prevent the virus’s entry and infection. Learn more on NIH RePORTER

Novel Role for the P2Y2 Receptor in SARS-CoV-2 Infection in the Oral Cavity

Dr. Gary Andrew Weisman
“These studies potentially offer an innovative translational approach in which a drug that modulates P2Y2 receptor activity could be administered to high-risk individuals, thereby blocking SARS-CoV-2 entry into oral epithelial cells and preventing the spread of this lethal virus.” —Gary Andrew Weisman

Gary Andrew Weisman
University of Missouri

Impeding the entry of SARS-CoV-2 into host oral epithelial cells may be a promising strategy for preventing viral infection. In previous studies, the researchers found that oral cell surface P2Y2 receptors have unique structural features that could play a role in SARS-CoV2 infection through the oral cavity. The researchers will determine whether P2Y2 receptors promote or inhibit SARS-CoV-2 interaction with cellular proteins known to facilitate the virus’s entry into host cells, and whether cells in the oral cavity are significant players in viral infectivity. Learn more on NIH RePORTER

Last Reviewed
December 2020