Stem Cell Biochemistry Section: Publications

Publications

• Bunker EN, Le Guerroué F, Wang C, Strub MP, Werner A, Tjandra N, et al. Nix Interacts with WIPI2 to Induce Mitophagy. EMBO J. 2023 Aug 25;e113491. doi: 10.15252/embj.2023113491.
• Asmar AJ, Abrams SR, Hsin J, Collins JC, Yazejian RM, Wu Y, et al. A tissue-specific ubiquitin switch coordinates early brain, craniofacial, and skin development. Nat Commun. 2023 Jul 26;14(1):4499.doi: 10.1038/s41467-023-40223-y.
• Stiburkova B, Pavelcova K, Belickova M, Magaziner SJ, Collins JC, Werner A, et al. Novel somatic UBA1 variant in a patient with VEXAS syndrome. Arthritits Rheumatol. 2023 Jul;75(7):1285-1290. doi:10.1002/art.42471. Epub 2023 May 11.
• Le Guerroué F, Bunker EN, Rosencrans WM, Nguyen JT, Basar MA, Werner A, et al. TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1. Mol Cell. 2023 Mar 16;83(6):927-941.e8. doi: 10.1016/j.molcel.2023.02.023. Epub 2023 Mar 9.
• Ferrada MA, Savic S, Ospina Cardona D, Collins JC, Alessi H, Wilson L, Goodspeed W, Topilow JS, Paik JJ, Poulter JA, Kermani TA, Koster MJ, Warrington KJ, Cargo C, Tattersall RS, Duncan CJA, Cantor A, Hoffmann P, Payne EM, Bonnekoh H, Krause K, Cowen EW, Calvo KR, Patel BA, Ombrello AK, Kastner DL, Young NS, Werner A, Grayson PC, Beck DB. Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis. Blood. 2022 Sep 29;140(13):1496-1506. doi:10.1182/blood.2022016985.
• Chatrathi HE, Collins JC, Wolfe LA, Markello TC, Adams DR, Gahl WA, Werner A, Sharma P. Novel CUL3 variant causing familial hyperkalemic hypertension impairs regulation and function of ubiquitin ligase activity. Hypertension. 2022 Jan;79(1):60-75. doi: 10.1161/HYPERTENSIONAHA.121.17624. Epub 2021 Dec 2.
• Poulter JA, Collins JC, Cargo C, de Tute RM, Evans P, Ospina Cardona D, Bowen DT, Cunnington JR, Baguley E, Quinn M, Green M, McGonagle D, Beck DB, Werner A, Savic S. Novel somatic mutations in UBA1 cause VEXAS syndrome. Blood. 2021 Jul 1;137(26):3676-3681. doi: 10.1182/blood.2020010286.
• • Beck DB, Basar MA, Asmar AJ, Thompson J, Oda H, Uehara DT, Saida K, Pajusalu S, Talvik I, D'Souza P, Bodurtha J, Mu W, Barañano KW, Miyake N, Wang R, Kempers M, Tamada T, Nishimura Y, Okada S, Kosho T, Dale R, Mitra A, Macnamara E; Undiagnosed Diseases Network; Matsumoto N, Inazawa J, Walkiewicz M, Õunap K, Tifft CJ, Aksentijevich I, Kastner DL, Rocha PP, Werner A. Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation. Sci Adv., 2021 Jan 20;7(4):eabe2116. doi: 10.1126/sciadv.abe2116.
• Beck DB, Ferrada MA, Sikora KA, Ombrello AK, Collins J, Pei W, Balanda N, Ross DL, Ospina Cardona D, Wu Z, Patel B, Manthiram K, Groarke EM, Gutierrez-Rodrigues F, Hoffmann P, Rosenzweig S, Nakabo S, Dillon LW, Hourigan CS, Tsai WL, Gupta S, Carmona-Rivera C, Asmar AJ, Xu L, Oda H, Goodspeed W, Barron KS, Nehrebecky M, Jones A, Laird RS, Deuitch N, Rowczenio D, Rominger E, Wells KV, Lee CR, Wang W, Trick M, Mullikin J, Wigerblad G, Brooks S, Dell'Orso S, Deng Z, Chae JJ, Dulau-Florea A, Malicdan MCV, Novacic D, Colbert RA, Kaplan MJ, Gadina M, Savic S, Lachmann HJ, Abu-Asab M, Solomon BD, Retterer K, Gahl WA, Burgess SM, Aksentijevich I, Young NS, Calvo KR, Werner A, Kastner DL, Grayson PC. Somatic mutations in UBA1 and severe adult-onset autoinflammatory disease. N Eng J Med. 2020 Dec 31;383(27):2628-2638. doi: 10.1056/NEJMoa2026834.
• Mena EL, Kjolby RAS, Saxton R, Werner A, Lew BG, Boyle JM, Harland R, Rape M. Dimerization quality control ensures neuronal development and survival. Science. 2018 Oct 12;362(6411):eaap8236. doi: 10.1126/science.aap8236. Epub 2018 Sep 6.
• Werner A, Baur R, Teerikorpi N, Kaya D, Rape M. Multisite dependency of an E3 ligase controls monoubiquitylation-dependent cell-fate decisions. Elife. 2018 Jul 12;7:e35407. doi: 10.7554/eLife.35407.
• Yau R, Doerner K, Castellanos ER, Haakonsen D, Werner A, Wang N, Yang XW, Martinez-Martin N, Matsumoto ML, Dixit VM, Rape M. Assembly and function of heterotypic ubiquitin chains in cell cycle and protein quality control. 2017 Cell. Nov 2;171(4):918-933.e20. doi: 10.1016/j.cell.2017.09.040.
• McGourty C, Akopian A, Walsh C, Gorur A, Werner A, Schekman R, Bautista D, Rape M. Regulation of the CUL3 ubiquitin ligase by a calcium-dependent co-adaptor. Cell. 2016 Oct 6;167(2):525-538.e14. doi: 10.1016/j.cell.2016.09.026.
• Werner A, Iwasaki S, McGourty C, Medina-Ruiz S, Teerikorpi N, Fedrigo I, Ingolia NT, Rape M. Cell-fate determination by ubiquitin-dependent regulation of translation. Nature. 2015 Sep 24;525(7570):523-527. doi:10.1038/nature14978.
• Werner A, Disanza A, Reifenberger N, Habeck G, Becker J, Calabrese M, Urlaub H, Lorenz H, Schulman B, Scita G, Melchior F. SCF(Fbxw5) mediates transient degradation of actin re-modeller Eps8 to allow proper mitotic progression. Nat Cell Biol. 2013 Feb;15(2):179-88. doi: 10:1038/ncb2661. Epub 2013 Jan 13.
• Bethani I, Werner A, Kadian C, Geumann U, Jahn R, Rizzoli SO. Endosomal fusion upon SNARE knockdown is maintained by residual SNARE activity and enhanced docking. Traffic. 2009 Oct;10(10):1543-59. doi: 10.1111/j.1600-0854.2009.00959.x. Epub 2009 Jun 22.

Reviews

• Beck DB, Werner A, Kastner DL, Aksentijevich I. Disorder of ubiquitylation: Unchained inflammation. Nat Rev Rheumatol. 2022 Aug;18(8):435-447. doi: 10.1038/s41584-022-00778-4.
• Basar MA, Beck DB, Werner A. Deubiquitylases in embryonic ubiquitin signaling and congenital diseases. Cell Death and Differ. 2021 Feb;28(2):538-556. doi: 10.1038/s41418-020-00697-5.
• Asmar AJ, Beck DB, Werner A. Control of craniofacial and brain development by Cullin3-RING ubiquitin ligases: Lessons from human disease genetics. Exp Cell Res. 2020 Nov 15;396(2):112300. doi: 10.1016/j.yexcr.2020.112300. Epub 2020 Sep 26.
• Werner A, Manford M, Rape M. Ubiquitin-dependent regulation of stem cell biology. Trends Cell Biol. Aug:27(8):568-579. doi: 10.1016/j.tcb.2017.04.002. Epub 2017 May 18.
• Williamson AP, Werner A, Rape M. The colossus of ubiquitylation: Decrypting a cellular code. Mol Cell. 2013 Feb 21;49(4):591-600. doi: 10.1016/j.molcel.2013.01.028.

Principal Investigator

Achim Werner, Ph.D.

Senior Investigator

Stem Cell Biochemistry Section

(301) 496-4563

Achim.Werner@nih.gov