Stem Cell Biochemistry Section: News
News
- A novel CUL3 variant that causes Familial Hyperkalemic Hypertension
Jan. 1, 2022
Check out our discovery and biochemical characterization of a new CUL3 variant causing hypertension and multiple congenital anomalies that provides new insights into the role of CRL3 complexes in human development. Congratulations to Jason and our collaborators from the Undiagnosed Diseases Program. - The Beck lab opens at NYU
Oct. 1, 2021
Congratulations and best wishes to David Beck. - David Beck receives NIH K99/R01 Pathway to Independence Award
Aug. 25, 2021
Congratulations, David. - Novel somatic mutations in UBA1 cause VEXAS syndrome Blood
Mar. 9, 2021
Check out our latest study describing new mutations that cause VEXAS syndrome. Congrats to Jason and David and thank you to Sinisca Savic, James Poulter, and team for a wonderful collaboration. - Deubiquitylases in developmental ubiquitin signaling and congenital diseases
Feb. 28, 2021
Our review summarizing the many ways DUBs shape ubiquitin signaling during embryonic and early postnatal development and how their dysregulation leads to congenital diseases is out. Congratulations to Basar and David. - Researchers Identify New Genetic Disorder that Affects Brain, Craniofacial Skeleton
Jan. 23, 2021
Our recent OTUD5 paper got highlighted by an NIH press release. - Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation
Jan. 21, 2021
Check out our discovery of a new multiple congenital disease we named LINKED syndrome and how studying its disease-causing mutations has revealed an essential role of OTUD5 in early developmental chromatin dynamics. Congratulations to David, Basar, and Anthony and thank you to a great collaboration with Kastner and Rocha labs at NHGRI and NICHD, respectively. - Control of craniofacial and brain development by Cullin3-RING ubiquitin ligases: lessons from human disease genetics
Sept. 25, 2020
Our first review is online. Check out the many ways Cullin3-RING ligases regulate craniofacial and brain development. Congratulations to Anthony and David. - Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease
Oct. 27, 2020
Our latest manuscript describing the discovery and the molecular basis of VEXAS, a novel severe adult-onset autoinflammatory disease, is online. What a fantastic collaborative effort from many labs at NIH. Congratulations to everyone, especially David, Jason, and Anthony. - Fellows Award for Research Excellence (FARE)
July 15, 2020
Congratulations to Anthony, Basar, and Jason for receiving the 2021 FARE award. - Regulation of Human Development by Ubiquitin Chain Editing of Chromatin Remodelers
Jan. 24, 2020
Our first manuscript describing how mutations in a deubquitylation enzyme lead to a novel multiple congenital anomaly disorder. Thanks to the Rocha and Kastner labs for wonderful collaboration.
Principal Investigator
Last Reviewed
January 2025
January 2025